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Objective To discuss family environment and parent's education pattern of violent online games addictive disorder in junior middle school students. Methods From August to December at 2008,6000 students were randomly drown from 8 junior middle schools in Dalian. All subjects were investigated with the self-made internet game survey form and the Chen internet addiction scale (CLAS). 149(2.5% ) internet game addicts were screen out from 6000 students, and then were divided into the violence and entertainment game addicted group (66 students in per group, and the male 55, female 11). No-game group 66 students were matched according tothe sex and the age. All subjects were evaluated with Egma Minnen av Bardndosnauppforstran ( EMBU) and Moss's Family Environment Scale of Chinese version. Results Lower mother's understand and warm were observed in violence internet online game addictive student group than other two groups( (46. 37 ± 13. 93,49. 80 ± 7.13,53. 16 ± 14. 89) , F = 4.88, P<0.01) ,and the mother understand and warm were remarkably lower in the violence online game addictive group than the non-game addicted group(P<0.01) ,and mothers rejection and the denial are obviously higher in entertainment online game addictive group than the non-game group(P = 0. 038). In family environment survey results suggested there were significant different during the 3 groups (F1-3 = 13. 99, 12.24,10.56; P<0.05)in emotion expression(4. 74 ± 1. 32,6. 06 ± 1. 97,5. 80 ± 1. 11) ,and conflict (5. 57 ± 1.85,5.28 ± 1.41,3.63 ± 1.50) .independence (3.96 ± 1. 87,4.56 ± 1.84,4.63 ± 1. 85). In the violence online game addictive group, emotion expression was lower than other two groups (P<0. 01) ,the conflict score was higher than other two groups (P<0.01). The controlling was lower than other two groups ( all P<0. 01) ; family function and total score are lower in online game addictive groups than other groups (P<0. 01, P<0. 05). Conclusion -Lower emotion expression,higher conflict,lacks of mother's love and warm,and lower controlling are found in violence online game addictive junior middle school students.
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Objective To assess the clinical effects of Shenfu injection which consists mainly of panaxoside and water-solubility alkaloied on chronic pulmonary heart disease complicated with heart failure.Methods Ninetysix patients were randomly divided into two groups ,40 patients underwent regular treatment (control group) and 56 patients were treated with Shenfu injection additionally to regular treatment (treatment group ).There were 2 treatment durations,with 15 days in one duration.The symptoms,left ventricular ejection fraction (LVEF) and B type UNa peptide (BNP) were measured before and after treatment.Results The total effective rate in the treatment group was 91.1% (51/56) ,which was significantly higher than that in the control group (72.5% ,29/40) (P ＜0.05 ).After treatment,the treatment group has significantly higher LVEF than the control group(53.27% ±7.45%vs.49.12% ± 5.89% ) ( P ＜ 0.05 ),and significantly lower BNP ( ( 209.1 ± 18.7 ) ng/L vs.( 261.2 ± 19.3 ) ng/L ( P ＜ 0.05).Conclusions Shenfu injection could strengthen the contractility and increase LVEF,therefore improve the function of left ventricle,as well as decrease BNP and repair heart failure.
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Objective To compare the diagnostic efficacy and complications of transperineal prostate biopsy for<10 cores biopsy vs≥10 cores biopsy. Methods Nine hundred transrectal ul-trasound-guided transperineal prostate biopsies were performed. Patients were divided into 2 groups, <10 cores group and ≥10 cores group. Patient numbers of the 2 groups were 759 and 141, respec-tively. Cancer positive rate and complications were compared between the 2 groups retrospectively. Results Cancer positive rates were 41.6%(316/759) and 51.8%(73/141) in 2 groups (P<0.05). In patients of PSA≤10.0 ng/ml, cancer positive rates were 6.8% (16/235) and 17.8% (8/45) in 2 groups (P<0.05). Gross hematuria was the most common complication associated with biopsy. There was no statistical difference between the 2 groups in post-biopsy gross hematuria rate. Conclu-sions The diagnostic efficacy is higher in≥10 cores prostate biopsy than that in <10 cores prostate biopsy, There is no difference in biopsy related complications regarding biopsy core numbers.
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Objective To study the clinical significance of the mRNA expression level of a novel gene which encodes a kind of transmembrane prostate protein induced by androgen-PMEPA1, as it may predict the progress of prostate cancer from hormone-dependent to hormone-independent. Methods We used Real-time PCR to detect the mRNA expression of PMEPA1 and GSTP1 in prostate cancer cell lines (LNCaP, PC-3), epithelia cells of benign prostatic hyperplasia and tissues from 33 patients with prostate cancers and 16 cases of prostatic hyperplasia. Results We found the mRNA expression of GSTP1 and PMEPA1 were both down-regulated in prostate cancer cell lines. The mRNA expression of GSTP1 was up-regulated in 6.1% of cases, down-regulated in 81.8%, and showed no difference in 12.1%. While PMEPA1 was highly expressed in 27.3% of cases, lowly expressed in 27.3%, and not differently expressed in 45.4%. Statistical analysis showed that the mRNA expression of GSTP1 was relevant to ages, but had no relationship with PSA, TNM stage, osseous metastasis or tumor differentiation, while the mRNA expression of PMEPA1 was relevant to osseous metastasis and tumor differentiation, but had no relationship with age, PSA or TNM stage. Conclusions PMEPA1 is possibly a useful biomarker, as it can identify patients with unfavourable prognosis, however, this hypothesis needs to be further studied with large samples.
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OBJECTIVE: To observe the clinical efficacy of nimodipine on cerebral infarction. METHODS: 120 patients with cerebral infarction were randomly selected into treatment group and control group(n=60). Both groups were given routine therapy, i.e. dehydration, neurotrophy, activating blood and dissolving stasis, lowering blood pressure, regulating blood lipid, lowering blood sugar and symptomatic treatment. Treatment group were additionally given oral dose of nimodipine 30 mg t.i.d. for 15 days. Clinical efficacies of 2 groups were observed and neurological impairment score before treatment and 15 days after treatment were evaluated. The change of hemorheology was detected by transcranial Doppler ultrasonography. RESULTS: The total effective rate of treatment group was 86.7%, which was significantly higher than that of control group(60.0%), there was significant difference between 2 groups(P